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According to the World Health Organization, “In the 20th century, the tobacco epidemic killed 100 million people worldwide. During the 21st century, it could kill one billion.”116 Year after year, at least 70% of surveyed smokers say they want to stop,117 and 40% make an attempt of at least one day.

 There is no lack of desire or effort. Sadly, what they do not know is “how.” Key to breaking free and staying free is an understanding of the “Law of Addiction.” Whether users know it by name or simply understand the basic premise, failure to self-discover or to be taught this law is a horrible reason to die.
The “Law of Addiction” is not man-made law. It is as fundamental as the law of gravity and refusal to abide by it may result in serious injury or death. The Law is rather simple. It states, “Administration of a drug to an addict will cause reestablishment of chemical dependence upon the addictive substance.” Mastering it requires acceptance of three fundamental principles:
(1) that dependency upon using nicotine is true chemical addiction, captivating the same brain dopamine reward pathways as alcoholism, cocaine or heroin addiction;
(2) that once established we cannot cure or kill an addiction but only arrest it;
and (3) that once arrested, regardless of how long we have remained nicotine free, that just one hit of nicotine will create a high degree of probability of a full relapse.

Quitting is a word that tugs at emotion. By definition it associates itself with departing, leaving, forsaking and abandonment. But the real abandonment took place on the day nicotine assumed control of our mind, when new salient memories made us forget that we functioned well without it, when we abandoned “us.” This book isn’t about quitting. It’s about recovering a person long forgotten, the real neuro-chemical “you.”

The word “quitting” tends to paint or dress nicotine cessation in gray and black, in the doom and gloom of bad and horrible. It breeds anticipatory fears, inner demons, needless anxieties, external enemies and visions of suffering. It fosters a natural sense of selfdeprivation, of leaving something valuable behind. Now contrast quitting with recovery. Recovery doesn’t run or hide from our addiction but instead boldly embraces every aspect of this temporary journey of re-adjustment. It sees The Journey Home 35 each symptom and challenge as a sign of the depth to which nicotine had infected our mind. When knowledge based, it recognizes the symptoms and celebrates each new challenge as an opportunity to reclaim yet another aspect of a life once drenched in nicotine.
Nicotine dependency recovery presents an opportunity to experience what may be our richest period of self-discovery ever. It’s a time when tissues heal, senses awaken and the brain’s neuro-chemicals again flow in response to life not nicotine. It’s a period where each challenge overcome awards the recovering addict another piece of a puzzle, a puzzle that once complete reflects a life reclaimed. It is not necessary that we delete the word “quit” from our thinking, vocabulary or this book but it might be helpful to reflect upon when the real “quitting” took place, when freedom ended and that next fix became life’s primary focus. Although nearly impossible to believe right now, you won’t be leaving anything of value behind - nothing.
Everything you did while using nicotine can be done as well, or better as “you.” All of the neurochemicals once controlled by nicotine were present before we started using and will gradually return to pre-nicotine levels. Every brain chemical that nicotine caused to flow is still present. They were always there and always yours.

Definitions of tolerance include:
1. Decreased responsiveness to a stimulus, especially over a period of continued exposure
2. The capacity to absorb a drug continuously or in large doses without adverse effect
3. Diminution in the response to a drug after prolonged use, or
4. Physiological resistance to a poison.
The brain attempts to fight back against its toxic intruder. As if it somehow knows that too much dopamine is flowing, it attempts to diminish the influence of nicotine by more widely disbursing it. It does so by growing or activating millions of extra nicotinic-type acetylcholine receptors in as many as eleven different brain regions.
 Although the average user’s body depletes and eliminates (metabolizes) nicotine at the rate of roughly one-half every two hours (129 minutes in Caucasians and 134 minutes in African Americans), the average nicotine intake per cigarette varies significantly.